The incidence and risk factors of selected drug prescriptions and outpatient care after SARS-CoV-2 infection in low-risk subjects: a multicenter population-based cohort study
Contributing partner:
Regional Agency for Health and Social Care of Emilia-Romagna Region (RER-ASSR)
Scientific article available at:
„Frontiers in Public Health“
Determinants of Anti-S Immune Response at 12 Months after SARS-CoV-2 Vaccination in a Multicentric European Cohort of Healthcare Workers—ORCHESTRA Project
Contributing partner:
University of Bologna (UNIBO)
Scientific article available at:
„Vaccines“
Studying temporal titre evolution of commercial SARS-CoV-2 assays reveals significant shortcomings of using BAU standardization for comparison
Contributing partner:
Ludwig-Maximilian-Universität München (LMU)
Scientific article available at:
„Virology“
Incidence and Determinants of Symptomatic and Asymptomatic SARS-CoV-2 Breakthrough Infections After Booster Dose in a Large European Multicentric Cohort of Health Workers-ORCHESTRA Project
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
„Journal of Epidemiology and Global Health“
Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
„eClinicalMedicine“
The Prospective COVID-19 Post-Immunization Serological Cohort in Munich (KoCo-Impf): Risk Factors and Determinants of Immune Response in Healthcare Workers
Contributing partner:
Ludwig-Maximilian-Universität München (LMU)
Scientific article available at:
„Viruses“
SARS-CoV-2 Reinfections in Health-Care Workers, 1 March 2020–31 January 2023
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
„Viruses“
Long-term Immune Response to SARS-CoV-2 Infection Among Children and Adults After Mild Infection
Contributing partner:
Fondazione Penta ONLUS (PENTA)
Scientific article available at:
„Pediatrics“
The representative COVID-19 cohort Munich (KoCo19): from the beginning of the pandemic to the Delta virus variant
Contributing partner:
Ludwig-Maximilian-Universität München (LMU)
Scientific article available at:
„BMC Infectious Diseases“
Using machine learning to predict antibody response to SARS-CoV-2 vaccination in Solid Organ Transplant Recipients.The multicentre ORCHESTRA cohort
Contributing partner:
University of Bologna (UNIBO)
Scientific article available at:
„Clinical Microbiology and Infection“
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
Contributing partner:
French National Institute of Health and Medical Research (INSERM)
Scientific article available at:
„Genome Medicine“
The Effect of the Immunization Schedule and Antibody Levels (Anti-S) on the Risk of SARS-CoV-2 Infection in a Large Cohort of Healthcare Workers in Northern Italy
Contributing partner:
University of Bologna (UNIBO)
Scientific article available at:
„Vaccines“
Diagnostic Accuracy of a Rapid SARS-CoV-2 Antigen Test Among People Experiencing Homelessness: A Prospective Cohort and Implementation Study
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
„Infectious Diseases and Therapy“
Integrative modelling of reported case numbers and seroprevalence reveals time-dependent test efficiency and infectious contacts
Contributing partner:
Ludwig-Maximilian-Universität München (LMU)
and Helmholtz Zentrum München (HMGU)
Scientific article available at:
„Epidemics“
Impact of Omicron variant infection on assessment of spike-specific Immune responses using Quan-T-Cell SARS-CoV-2 assay and Roche Elecsys anti-SARS-CoV-2-S
Contributing partner:
Ludwig-Maximilian – Universität München (LMU)
Scientific article available at:
„Pathology and Molecular Diagnostics“
Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments
Contributing partner:
University of Antwerp (UAntwerp)
University of Verona (UNIVR)
Scientific article available at:
„JCI The Journal of Clinical Investigation“
Relationship between immune response to SARS-CoV2 vaccines and development of breakthrough infection in solid organ transplant recipients: the CONTRAST cohort
Contributing partner:
University of Bologna (UNIBO)
Scientific article available at:
„Clinical Infectious Diseases“
SARS-CoV-2 Breakthrough Infections in Health Care Workers: An Italian Retrospective Cohort Study on Characteristics, Clinical Course and Outcomes
Contributing partner:
University of Bologna (UNIBO)
Scientific article available at:
„J. Clin. Med.“
Temporal trends of COVID-19 antibodies in vaccinated healthcare workers undergoing repeated serological sampling: An individual-level analysis within 13 months in the ORCHESTRA cohort
Contributing partner:
University of Bologna (UNIBO)
Scientific article available at:
„Frontiers in Immunology“
Effectiveness of prevention of SARS-CoV-2 transmission among unvaccinated Italian healthcare workers
Contributing partner:
University of Bologna (UNIBO)
Scientific article available at:
„Med Lav“
Primary SARS-CoV-2 Infections, Re-infections and Vaccine Effectiveness during the Omicron Transmission Period in Healthcare Workers of Trieste and Gorizia (Northeast Italy), 1 December 2021–31 May 2022
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
„Viruses“
Exploratory data on the clinical efficacy of monoclonal antibodies against SARS-CoV-2 Omicron Variant of Concern
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
eLife (elifesciences.org)
SARS-CoV-2 and Its Variants in Thrice-Infected Health Workers: A Case Series from an Italian University Hospital
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
„Viruses
Retrospective analysis of SARS-CoV-2 omicron invasion over delta in French regions in 2021–22: a status-based multi-variant model
Contributing partner:
French National Institute of Health and Medical Research (INSERM)
Scientific article available at:
„BMC Infectious Diseases“
The COVID HOME study research protocol: Prospective cohort study of non-hospitalised COVID-19 patients
Contributing partner:
University Medical Center Groningen (UMCG)
Scientific article available at:
„PLOS ONE“
Predictors of clinical evolution of SARS-CoV-2 infection in hematological patients: A systematic review and meta-analysis
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
„Hematological Oncology“
Association of Patients’ Epidemiological Characteristics and Comorbidities
with Severity and Related Mortality Risk of SARS-CoV-2 Infection: Results of
an Umbrella Systematic Review and Meta-Analysis
Contributing partner:
Servicio Andaluz de Salud (SAS)
Scientific article available at:
„Biomedicines“
Perceived Psychological Impact on Children and Parents of Experiencing COVID-19 Infection in One or More Family Members
Contributing partner:
Fondazione Penta ONLUS (PENTA)
Scientific article available at:
„Children“
Usefulness and Limitations of Anti-S IgG Assay in Detecting Previous SARS-Cov-2 Breakthrough Infection in Fully Vaccinated Healthcare Workers
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
„Diagnostics“
Clinical Impact of Monoclonal Antibodies in the Treatment of High-Risk Patients with SARS-CoV-2 Breakthrough Infections: The ORCHESTRA Prospective Cohort Study
Contributing partner:
University of Bologna (UNIBO)
Helmholtz Zentrum München (HMGU)
University of Antwerp (UAntwerp)
Scientific article available at:
„Biomedicines“
Challenges of data sharing in European Covid-19 projects: A learning opportunity for advancing pandemic preparedness and response
Contributing partner:
University of Verona (UNIVR)
University Medical Center Groningen (UMCG)
Scientific article available at:
„The Lancet Regional Health – Europe“
SARS-CoV-2 Breakthrough Infections: Incidence and Risk Factors in a Large European Multicentric Cohort of Health Workers
Contributing partner:
University of Bologna (UNIBO)
University of Verona (UNIVR)
Scientific article available at:
„Vaccines“
Exhaustion in Healthcare Workers after the First Three Waves of the COVID-19 Pandemic
Contributing partner:
National Institute of Public Health (INSP)
Scientific article available at:
„International Journal of Environmental Research and Public Health“
Assessment of neutralizing antibody responses after natural SARS-CoV-2 infection and vaccination in congolese individuals
Contributing partner:
The Congolese Foundation for Medical Research (FCRM)
Scientific article available at:
„BMC Infectious Diseases“
Preliminary Evidence on Pulmonary Function after Asymptomatic and Mild COVID-19 in Children
Contributing partner:
Fondazione Penta ONLUS (PENTA)
Scientific article available at:
„Children“
Clinical efficacy of different monoclonal antibody regimens among non-hospitalised patients with mild to moderate COVID-19 at high risk for disease progression: a prospective cohort study
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
„European Journal of Clinical Microbiology & Infectious Diseases“
Harmonization and standardization of data for a pan-European cohort on SARS- CoV-2 pandemic
Contributing partner:
Berlin Institute of Health (BIH/Charité)
Scientific article available at:
„npj Digital Medicine“
Social Isolation Among Older Adults in the Time of COVID-19: A Gender Perspective
Contributing partner:
French national institute of health and medical research (INSERM)
Scientific article available at:
„Frontiers in Public Health“
Trends in social exposure to SARS-Cov-2 in France. Evidence from the national socio-epidemiological cohort–EPICOV
Contributing partner:
French National Institute of Health and Medical Research (INSERM)
Scientific article available at:
„PLOS ONE“
Evaluation of the Kinetics of Antibody Response to COVID-19 Vaccine in Solid Organ Transplant Recipients: The Prospective Multicenter ORCHESTRA Cohort
Contributing partner:
University of Bologna (UNIBO)
Scientific article available at:
„Microorganisms“
Serological response after SARS-CoV2 vaccination in healthcare workers: a multicenter study
Contributing partner:
University of Bologna (UNIBO)
Scientific article available at:
„La Medicina del Lavoro, Journal of the Italian Society of Occupational Health“
Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis
Contributing partner:
University of Bologna (UNIBO)
University of Verona (UNIVR)
Servicio Andaluz de Salud (SAS)
Scientific article available at:
„Clinical Microbiology and Infection“
Risk and severity of SARS-CoV-2 infection in breast cancer patients undergoing a structured infection screening program at the University and Hospital Trust of Verona
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
„Annals of Oncology“
Protective SARS-CoV-2 Antibody Response in Children With Inflammatory Bowel Disease
Contributing partner:
Fondazione Penta ONLUS (PENTA)
Scientific article available at:
„Frontiers in Pediatrics“
Determinants of persistence of symptoms and impact on physical and mental wellbeing in Long COVID: A prospective cohort study
Contributing partner:
University of Verona (UNIVR)
Scientific article available at:
„Journal of Infection“
Spatially resolved qualified sewage spot sampling to track SARS-CoV-2 dynamics in Munich – One year of experience
Contributing partner:
Ludwig-Maximilian- Universität München (LMU)
Scientific article available at:
„Science of The Total Environment“
Seroepidemiology and model-based prediction of SARS-CoV-2 in Ethiopia: longitudinal cohort study among front-line hospital workers and communities
Contributing partner:
Ludwig-Maximilian – Universität München (LMU)
and Helmholtz Zentrum München (HMGU)
Scientific article available at:
„The Lancet Global Health“
ORCHESTRA project in Romania – a prospective occupational cohort to study the impact of COVID-19 pandemic on healthcare workers
Contributing partner:
National Institute of Public Health (INSP)
Scientific article available at:
„Romanian Journal of Occupational Medicine“
From first to second wave: follow-up of the prospective Covid-19 cohort (KoCo19) in Munich (Germany)
Contributing partner:
Ludwig-Maximilian- Universität München (LMU)
Scientific article available at:
„BMC infectious diseases“
Mild SARS-CoV-2 Infections and Neutralizing Antibody Titers
Contributing partner:
Fondazione Penta ONLUS (PENTA)
Scientific article available at:
„PEDIATRICS®“
A dried blood spot protocol for high throughput analysis of SARS-CoV-2 serology based on the Roche Elecsys anti-N assay
Contributing partner:
Ludwig-Maximilian – Universität München (LMU)
Scientific article available at:
„eBioMedicine“
Broad T Cell Targeting of Structural Proteins After SARS-CoV-2 Infection: High Throughput Assessment of T Cell Reactivity Using an Automated Interferon Gamma Release Assay
Contributing partner:
Ludwig-Maximilian- Universität München (LMU)
Scientific article available at:
“Frontiers in Immunology”
Left ventricle longitudinal strain alterations in asymptomatic or mildly symptomatic pediatric patients with recent SARS-CoV-2 infection
Contributing partner:
Fondazione Penta ONLUS (PENTA)
Scientific article available at:
“European Heart Journal – Cardiovascular Imaging”
The following overview shows all deliverables. Approved and public deliverables can be downloaded.
| Del Rel. No | Title | Lead Beneficiary | Dissemination level and availability |
D1.1 |
Project Management Guidelines |
UNIVR |
Download |
D1.2 |
Revised project plan following kick off meeting |
UNIVR |
Confidential, approved |
D1.3 |
Database for Ethics Approval |
UNIVR |
Confidential, approved |
D1.4 |
Portfolio presentations of final Conference |
UNIVR |
Public, in progress |
D1.5 |
Interim activity report |
UNIVR |
Confidential, approved |
D1.6 |
Ethics Board Report Interim |
UNIVR |
Confidential, approved |
D1.7 |
Ethics Board Report Final |
UNIVR |
Confidential, in progress |
D2.1 |
Systematic review of the literature on determinants of COVID-19 manifestation/ progression |
SAS |
Download |
D2.2 |
Algorithms for supporting clinical decision-making for COVID-19 patients |
INSERM |
Public, in progress |
D2.3 |
Algorithms for guiding therapeutic decisions for COVID-19 patients |
UHC |
Public, in progress |
D2.4 |
Algorithms for management of long term sequelae of COVID-19 individuals |
UNIVR |
Public, in progress |
D2.5 |
Final report of 6-month follow up by clinical, immunological and virological features |
UNIVR |
Download |
D2.6 |
Final report of 12-month follow up by clinical, immunological and virological features |
UNIVR |
Public, in progress |
D2.7 |
Assessment of clinical and epidemiological characteristics of post-COVID-19 syndrome at 24-month follow-up (final report) |
UNIVR |
Public, in progress |
D3.1 |
Guiding principles report on type and source of population cohorts |
INSERM |
Confidential, approved |
D3.2 |
Preliminary report on seroprevalence in EU countries |
INSERM |
Download |
D3.3 |
Report on genotypic and epigenetic features related to infection |
HMGU |
Public, in progress |
D3.4 |
Report on consequences of lockdown and other prevention measures on health |
LIH |
Public, in progress |
D3.5 |
Report on the serological immune responses of non-vaccinated infected, vaccinated, and breakthrough infected individuals |
LMU MUENCHEN |
Public, in progress |
D3.6 |
Identification of break-through infections in population-based cohorts |
LMU MUENCHEN |
Public, in progress |
D4.1 |
Report on ORCHESTRA-fragile population |
UNIBO |
Confidential, approved |
D4.2 |
Protocol for prospective cohort of vaccinated and non vaccinated fragile patients |
UNIBO |
Confidential, approved |
D4.3 |
Quality and kinetic of early immune response to COVID-19 vaccination in fragile patients |
UNIBO |
Download |
D4.4 |
Quality and kinetic of long-term immune response to COVID-19 vaccination in fragile patients (interim report) |
UNIBO |
Public, in progress |
D4.5 |
Clinical algorithms for diagnostic and therapeutic management of SARS-CoV-2 infection in fragile populations |
SAS |
Public, in progress |
D4.6 |
Clinical algorithms for long-term management of COVID-19 in fragile patients |
UNIVR |
Public, in progress |
D4.7 |
Report of consequences of lockdown and preventive measures on the management of fragile cohorts |
UNIBO |
Public, in progress |
D4.8 |
Quality and kinetic of long-term immune response to booster dosages of COVID-19 vaccination in fragile patients |
UNIBO |
Public, in progress |
D4.9 |
Burden and management of persisting COVID-19 in severe immunocompromised patients |
UNIBO |
Public, in progress |
D5.1 |
Datasets of clinical and microbiological data of the HCWs cohort |
UNIBO |
Confidential, in progress |
D5.2 |
Results of analysis of determinants of COVID-19 and their longitudinal changes among HCWs |
UNIBO |
Public, in progress |
D5.3 |
Report on feasibility of enrolling vaccinated HCWs in phase 4 vaccine trials |
UNIBO |
Public, in progress |
D5.4 |
Guidance for prevention of SARS-CoV-2 infection in HCWs |
UNIOVI |
Public, in progress |
D5.5 |
Interim analysis of serology results after vaccination |
UNIBO |
Download |
D5.6 |
Immunological response in vaccinated and not vaccinated HCWs (temporal trend) final |
UNIBO |
Download |
D5.7 |
First interim risk analysis of breakthrough infection |
LMU MUENCHEN |
Download |
D5.8 |
Incidence of breakthrough infections |
LMU MUENCHEN |
Download |
D5.9 |
Final risk analysis of breakthrough infection |
LMU MUENCHEN |
Public, in progress |
D5.10 |
Final analysis of serology results after vaccination |
UNIBO |
Download |
D5.11 |
Risk analysis of breakthrough infection in healthcare workers cohort at 36-month follow up (final report) |
UNIVR |
Public, in progress |
D5.12 |
Analysis of serology results after vaccination in healthcare workers at 36-month follow-up (final report) |
UNIBO |
Public, in progress |
D5.13 |
Analysis of post-COVID-19 syndrome in HCW (final report) |
UNIOVI |
Public, in progress |
D6.1 |
Standardised protocol and manual on collection and storage of samples |
UANTWERPEN |
Confidential, approved |
D6.2 |
Dataset of human genome sequencing of patients with COVID-19 from retrospective cohorts |
UNIBO |
Download |
D6.3 |
Report on viral loads, viral genome sequences of retrospective cohorts |
INSERM |
Download |
D6.4 |
Report on serology analysis of retrospective COVID-19 cohorts |
INSERM |
Download |
D6.5 |
Report on cytokine chemokine analysis in COVID-19 patients from retrospective cohorts |
UANTWERPEN |
Download |
D6.6 |
First report on serology in fragile populations |
INSERM |
Download |
D6.7 |
First report on immunity analysis from prospective cohorts (COVID-19, vaccinated and not vaccinated) |
UANTWERPEN |
Download |
D6.8 |
Report on viral loads, viral genome sequences on prospective cohorts (preliminary report) |
INSERM |
Download |
D6.9 |
Final report on cellular immunity analysis for prospective cohorts (COVID-19, vaccinated and not vaccinated) |
UANTWERPEN |
Public, in progress |
D6.10 |
Dataset of 16S rRNA sequencing of retrospective cohorts |
UNIBO |
Download |
D6.11 |
Dataset of human genomic sequencing outcome of patients from prospective COVID-19 cohorts |
UNIBO |
Public, in progress |
D6.12 |
Report on dataset of genome-wide methylation patterns |
HMGU |
Public, in progress |
D6.13 |
Report on serology analysis including long-term sequelae and natural immunity (WP2) |
UANTWERPEN |
Public, in progress |
D6.14 |
Report on cytokine chemokine analysis in COVID-19 patients (including long-term sequelae) |
UANTWERPEN |
Public, in progress |
D6.15 |
Final report on dataset of human genetic variants enriched in COVID-19 |
UNIBO |
Public, in progress |
D6.16 |
Report on respiratory and gut microbiome (dynamics for all cohorts) |
UANTWERPEN |
Public, in progress |
D6.17 |
Report on functional validation of human genetic variants enriched in COVID-19 patients |
UNIBO |
Public, in progress |
D6.18 |
Report on viral genome sequences and serology in case of breakthrough infections |
UANTWERPEN |
Public, in progress |
D6.19 |
Report on cellular immunity analysis for prospective cohorts (COVID-19, vaccinated and not vaccinated) at 24-month follow up (final report) |
UANTWERPEN |
Public, in progress |
D6.20 |
Report on viral genome sequences and serology in breakthrough infections (final report) |
UANTWERPEN |
Public, in progress |
D7.1 |
Data Management Plan |
CINES |
Confidential, approved |
D7.2 |
Report on harmonisation of data collection and standardisation of protocols |
Charité |
Confidential, in progress |
D7.3 |
First version of report on Data Protection and Access Policy |
Charité |
Confidential, approved |
D7.4 |
Report on feasibility assessment of statistical analysis within modelling workflow |
CINES |
Confidential, approved |
D7.5 |
Report on NHs |
USTUTT |
Confidential, in progress |
D7.6 |
First report on ORCHESTRA portal: a preliminary prototype with reduced functionalities required for non sensitive data. Second, intermediate report on ORCHESTRA portal. Final report on ORCHESTRA portal |
CINECA |
Confidential, approved |
D7.7 |
Second version of report on Data Protection and Access Policy |
Charité |
Confidential, in progress |
D7.8 |
Update on data management plan |
CINES |
Confidential, in progress |
D8.1 |
Report on estimates of intervention effects using compartment model |
HMGU |
Download |
D8.2 |
Report on estimates of intervention effects using individual-based models |
HMGU |
Public, in progress |
D8.3 |
Report on risk associated with socio-economic factors |
ISGLOBAL |
Public, in progress |
D8.4 |
Report on impact of pandemic on socio-economic indicators |
ISGLOBAL |
Public, in progress |
D8.5 |
Report on impact of delayed service on fragile populations |
ISGLOBAL |
Public, in progress |
D8.6 |
Report on assessment of intra-host viral dynamics and immunity half-life |
INSERM |
Public, in progress |
D8.7 |
In silico model of vaccination strategies |
HMGU |
Download |
D8.8 |
Final report on translation of strategies to LMICs |
ISGLOBAL |
Public, in progress |
D8.9 |
Report on the impact of the pandemic on healthcare services use in Gabon |
ISGLOBAL |
Public, in progress |
D9.1 |
Working plan |
UMCG |
Confidential, approved |
D9.2 |
Protocol Evaluation Framework |
UMCG |
Confidential, approved |
D9.3 |
Consortium agreement with new Cohorts |
UMCG |
Confidential, approved |
D9.4 |
Final document with scientific highlights |
UNIVR |
Public, in progress |
D10.1 |
Communication and dissemination strategy plan and website online |
UHC |
Download |
D10.2 |
Social media accounts created and accredited |
UHC |
Download |
D10.3 |
First regular graphics visualized |
UHC |
Download |
D10.4 |
Anonymous dataset for the public published |
UHC |
Download |
D10.5 |
Call for first science challenge based on anonymized project dataset |
UHC |
Download |
D10.6 |
Cohort Builder and Dashboard online |
UHC |
Download |
D10.7 |
Automated emails service for stakeholders |
UHC |
Download |
D11.1 |
H – Requirement No. 1 |
UNIVR |
Confidential, approved |
D11.2 |
H – Requirement No. 2 |
UNIVR |
Public, in progress |
D11.3 |
HCT – Requirement No. 3 |
UNIVR |
Confidential, approved |
D11.4 |
HCT – Requirement No. 4 |
UNIVR |
Confidential, approved |
D11.5 |
POPD – Requirement No. 6 |
UNIVR |
Confidential, approved |
D11.6 |
NEC – Requirement No. 7 |
UNIVR |
Confidential, approved |
Acknowledgements
ORCHESTRA has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101016167. [Long version]
***
Supported by the H2020-RIA GA No 101016167. [Short version]
***
All publications of research results or information from EU-funded projects must be clearly marked with the EU-emblem (EU-flag) and information about the financial funding mechanism.
You need to acknowledge the EU-funding when:
writing articles in newspapers, journals
being interviewed e.g. for a newspaper, journal, radio, tv programme
producing printed material such as brochures/leaflets/posters
having presentations in public fora, e.g. conferences, seminars
For more information, please consult the ORCHESTRA Publication Policy, available upon request: pmu@orchestra-cohort.eu
Disclaimer clause
The views expressed in this [publication/document/paper…] are the sole responsibility of the author and the Commission is not responsible for any use that may be made of the information it contains.